Skip to main content

TABLE 1.

Neutralization of HPIV3 and HPIV3/EboGP with anti-HPIV3 and/or anti-EV antibodies

Virus Cells Antibody dilution Amt of infectious virus (log10 PFU) following neutralization witha:
Anti-HPIV3 Anti-EV Anti-HPIV3 + anti-EV
HPIV3 LLC-MK2 1:10 <1.2 3.9 <1.2
1:40 <1.2 NDb <1.2
No antibody 4.7 4.6 4.6
Vero 1:10 <1.2 3.9 <1.2
1:40 <1.2 ND <1.2
No antibody 4.8 4.8 4.7
HPIV3/EboGP LLC-MK2 1:10 3.2 <1.2 1.2
1:40 3.7 2.1 2.6
No antibody 4.7 4.7 4.7
Vero 1:10 3.6 1.7 1.9
1:40 3.9 2.3 2.7
No antibody 4.9 5.1 5.2
a

The indicated viruses (105.2 PFU) were incubated with the indicated dilution of anti-HPIV3 antibodies, anti-EV antibodies, or their mixture in the presence of complement. After the incubation, the residual infectivity was determined on day 7 by plaque titration in the indicated cell lines.

b

ND, not determined.