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. 2006 Mar;80(5):2280–2290. doi: 10.1128/JVI.80.5.2280-2290.2006

FIG. 3.

FIG. 3.

Detection of HCV genomes and replicative-intermediate RNAs in portal and lobular regions of liver biopsy specimens. Panels A and D show positive staining of HCV genomes and replicative-intermediate RNAs, respectively, in a portal region under ×10 magnification (serial sections from the same specimen). Panels B and E show ×100 magnifications of the indicated areas of the biopsy specimen, demonstrating abundant HCV genomes and replicative-intermediate RNAs in cells with morphological features not typical of hepatocytes. Panels C and F show ×100 magnifications of hepatocytes in a different specimen, demonstrating a focal pattern of HCV genome accumulation (panel C) and perinuclear localization of punctate signals for RI RNA (panel F, arrows).