TABLE 1.
Development of diabetes in NOD mice infected with reovirus strain T3Aa
| Inoculum | No. of mice with diabetes/no. tested (%) in expt
|
|
|---|---|---|
| I | II | |
| Control | 7/8 (88) | 19/23 (83) |
| T3A | 3/14 (21) | 11/17 (65) |
a
Two-day-old NOD mice were inoculated intraperitoneally with 1 × 105 PFU of T3A; control animals were inoculated intraperitoneally with an equivalent volume of L929 cell lysate diluted in pyrogen-free normal saline. Glucose homeostasis in infected and control mice was monitored for 30 weeks. Only female mice were included in the analysis.