FIG. 8.

Northern blot analysis of total RNA extracts of the livers of an HBV-transgenic mouse (lane 1), a patient with HBV-induced FCH (lane 2), a noninfected chimeric mouse (lane 3), a short-term HBV-infected mouse (lane 4), and a long-term HBV-infected mouse (lane 5). From each sample 10 μg of total RNA was loaded. The Pre-S1 transcript can be easily seen in the long-term-infected chimeric mouse. The lower hGAPDH signal in the short-term-infected mouse reflects a lower amount of human hepatocytes present in the chimeric liver.