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. 2006 Mar 9;116(4):1081–1091. doi: 10.1172/JCI26640

Figure 5. Inhibition of hypothalamic CPT1A expression restrains liver glucose fluxes in OF rats.

Figure 5

(A) On day 0, icv cannulae were surgically implanted. Arterial and venous catheters were placed on day 14, and icv injections of CPT1A-Ribo or control vector were performed on day 19 following 2 days of overfeeding. Clamp studies were performed on day 21. Rats receiving vector as control were pair-fed to the level of CPT1A-Ribo. (B) Pancreatic insulin clamp procedure. (C) Glucose infusion rate during the clamp in SC or OF rats. (D) Inhibition of glucose production during the clamp period expressed as percent decrease from basal glucose production. CPT1A-Ribo markedly reduced the flux through G6Pase (E) and gluconeogenesis (F) and suppressed G6pc (G) and Pck1 (H) gene expression in SC and OF rats. *P < 0.05 rsus control.