. Author manuscript; available in PMC: 2006 Mar 9.

Published in final edited form as: J Biol Chem. 2005 Sep 29;280(47):39474–39484. doi: 10.1074/jbc.M504672200

TABLE TWO.

Quantitative analysis of platelet morphology following adhesion to fibrinogen Purified wild-type (WT) and Rac1^-/-Rac2^-/- murine platelets (2 × 107/ml) were placed on coverslips coated with fibrinogen for 45 min. Platelets were treated with apyrase (2 units/ml) and indomethacin (10 μM) in the absence or presence of 1 unit/ml thrombin. The length and thickness of filopodial protrusions were determined as described under “Experimental Procedures.” Values are reported as follows: mean ± S.E. of at least 100 cells.

Genotype	Treatment No.	filopodia per cell	Length of filopodia	Thickness of filopodia
			μm	μm
WT		9.6 ± 0.20	0.92 ± 0.02	0.50 ± 0.01
Rac1^-/-Rac2^-/-		9.8 ± 0.19	0.89 ± 0.02	0.48 ± 0.01
Rac1^-/-Rac2^-/-	Thrombin	9.7 ± 0.09	2.05 ± 0.04^a	0.74 ± 0.01^a

p < 0.01 with respect to no treatment control.