. Author manuscript; available in PMC: 2006 Mar 9.

Published in final edited form as: J Biol Chem. 2005 Sep 29;280(47):39474–39484. doi: 10.1074/jbc.M504672200

TABLE FOUR.

Role of Rac1/Rac2 on platelet adhesion to collagen under flow Murine whole blood specimens were incubated for 10 min at 37 °C prior to being perfused for 4 min over either a collagen-coated or VWF/thrombin-coated surface at 1000 s[H11002]1. Platelet adhesion is expressed as the percentage of surface covered by platelets for five fields of view (1.3 × 104 μm²). Values are reported as mean ± S.E. of three experiments.

Genotype	Surface	Platelet adhesion to collagen
		% surface coverage
WT	Collagen	51.7 ± 2.11
WT	VWF	35.9 ± 3.07
Rac1^-/-Rac2^-/-	Collagen	19.1 ± 1.13^a
Rac1^-/-Rac2^-/-	VWF	9.34 ± 0.80^a

p < 0.01 with respect to no treatment (wild type).