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. 2001 Jul;13(7):1609–1624. doi: 10.1105/TPC.010168

Figure 1.

Figure 1.

Alignment of the Predicted Amino Acid Sequences of HDC1 and Related Genes.

(A) Proteins shown are the products of HOS2 of S. cerevisiae (Rundlett et al., 1996; SWISS-PROT accession number P53096), HOSA of A. nidulans (Graessle et al., 2000; GenBank accession number AF164342), and HDC1 of C. carbonum (GenBank accession number AF306507) using CLUSTAL W (Thompson et al., 1994). Amino acids that are identical in all three proteins are indicated by asterisks. Sixteen of the 17 amino acids that are highly conserved in all RPD3-like HDAs and related bacterial proteins are underlined (Hassig et al., 1998).

(B) Unrooted cladogram showing relatedness of HDAC proteins. HosA and RpdA are from A. nidulans (An; Graessle et al., 2000). Hda1, Rpd3, Hos1, Hos2, and Hos3 are from S. cerevisiae (SC; Vidal and Gaber, 1991; Rundlett et al., 1996). Hdc1, Hdc2, and Hdc3 are from C. carbonum (Cc; this article; D. Baidyaroy and J.D. Walton, unpublished data; E-M. Brandtner, S. Graessle, and G. Brosch, unpublished data). Contigs 1.1059, 1.91, 1.17, and 1.451 represent predicted proteins from the eponymous genomic DNA sequences of N. crassa (Nc; http://www.genome.wi.mit.edu/annotation/fungi/neurospora/). The units on the scale at bottom are numbers of substitution events.