TABLE 2.
Changes in MICs as a result of ssa inactivation
| Antibiotic | MIC (μg/ml) for strain:
|
||
|---|---|---|---|
| SAM1010 (Ts) [yycF1(Ts) ermB] | SAM1011 (ermB) | SAM1011s1 (ssa::tetK ermB) | |
| Macrolides (14 and 16 membered) and lincosamides | |||
| Erythromycin | 16 | >512 | 8 |
| Roxithromycin | 32 | >512 | 4 |
| Josamycin | 8 | >512 | 2 |
| Tylosin tartrate | 4 | >512 | 2 |
| Lincomycin | 1 | >512 | 2 |
| Clindamycin | 0.25 | >512 | 0.25 |
| Representative non-MLSB-type antibiotics | |||
| Chloramphenicol | 16 | 16 | 8 |
| Phleomycin | 4 | 4 | 4 |
| Streptomycin | 2 | 2 | 2 |
| Vancomycin | 1 | 1 | 1 |
| Methicillin | 1 | 1 | 1 |
| Norfloxacin | 0.5 | 0.5 | 0.5 |