Skip to main content
PMC home page
Annals of Surgery logoLink to Annals of Surgery
. 1977 Nov;186(5):651–658. doi: 10.1097/00000658-197711000-00018

Parenteral nutrition in the treatment of acute pancreatitis: effect on complications and mortality.

J T Goodgame, J E Fischer
PMCID: PMC1396309  PMID: 411429

Abstract

Clinical characteristics of 46 cases of acute pancreatitis treated with total parenteral nutrition were examined. Hyperalimentation may be used in these severely ill patients with minimal technical or metabolic morbidity. This method of nutritional support can maintain patients with nonfunctional gastrointestinal tracts for several months. Catheter-related sepsis was more common than expected early in the course of acute pancreatitis but caused minimal morbidity. The incidence of catheter-related sepsis late in disease was minor. Hyperalimentation had little if any effect on the pathophysiology of acute pancreatitis as judged by the overall mortality and the incidence and severity of the complications of acute respiratory failure and acute renal failure. It is not clear that parenteral hyperalimentation alters the course of acute pancreatitis but it is a useful adjunct for nutritional support in this illness.

Full text

PDF

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abel R. M., Abbott W. M., Fischer J. E. Intravenous essential L-amino acids and hypertonic dextrose in patients with acute renal failure. Effects on serum potassium, phosphate, and magnesium. Am J Surg. 1972 Jun;123(6):632–638. doi: 10.1016/0002-9610(72)90343-1. [DOI] [PubMed] [Google Scholar]
  2. Copeland E. M., 3rd, MacFadyen B. V., Jr, McGown C., Dudrick S. J. The use of hyperalimentation in patients with potential sepsis. Surg Gynecol Obstet. 1974 Mar;138(3):377–380. [PubMed] [Google Scholar]
  3. ESKWITH I. S., CACACE V. A., SOLLOSY A. Acute hemorrhagic pancreatitis; treatment with cortisone. N Engl J Med. 1955 Mar 24;252(12):494–495. doi: 10.1056/NEJM195503242521206. [DOI] [PubMed] [Google Scholar]
  4. FARBER E., POPPER H. Production of acute pancreatitis with ethionine and its prevention by methionine. Proc Soc Exp Biol Med. 1950 Aug;74(4):838–840. doi: 10.3181/00379727-74-18062. [DOI] [PubMed] [Google Scholar]
  5. Feller J. H., Brown R. A., Toussaint G. P., Thompson A. G. Changing methods in the treatment of severe pancreatitis. Am J Surg. 1974 Feb;127(2):196–201. doi: 10.1016/0002-9610(74)90157-3. [DOI] [PubMed] [Google Scholar]
  6. Fischer J. E., Foster G. S., Abel R. M., Abbott W. M., Ryan J. A. Hyperalimentation as primary therapy for inflammatory bowel disease. Am J Surg. 1973 Feb;125(2):165–175. doi: 10.1016/0002-9610(73)90022-6. [DOI] [PubMed] [Google Scholar]
  7. Frey C. F. The operative treatment of pancreatitis. Arch Surg. 1969 Apr;98(4):406–417. doi: 10.1001/archsurg.1969.01340100038003. [DOI] [PubMed] [Google Scholar]
  8. Gordon D., Calne R. Y. Renal failure in acute pancreatitis. Br Med J. 1972 Sep 30;3(5830):801–802. doi: 10.1136/bmj.3.5830.801. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Hamilton R. F., Davis W. C., Stephenson D. V., Magee D. F. Effects of parenteral hyperalimentation on upper gastrointestinal tract secretions. Arch Surg. 1971 Apr;102(4):348–352. doi: 10.1001/archsurg.1971.01350040110022. [DOI] [PubMed] [Google Scholar]
  10. Interiano B., Stuard I. D., Hyde R. W. Acute respiratory distress syndrome in pancreatitis. Ann Intern Med. 1972 Dec;77(6):923–926. doi: 10.7326/0003-4819-77-6-923. [DOI] [PubMed] [Google Scholar]
  11. Knight M. J., Condon J. R., Smith R. Possible use of glucagon in the treatment of pancreatitis. Br Med J. 1971 May 22;2(5759):440–442. doi: 10.1136/bmj.2.5759.440. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Lawson D. W., Daggett W. M., Civetta J. M., Corry R. J., Bartlett M. K. Surgical treatment of acute necrotizing pancreatitis. Ann Surg. 1970 Oct;172(4):605–617. doi: 10.1097/00000658-197010000-00007. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. MCHARDY G., CRAIGHEAD C. C., BALART L., MCHARDY R. CURRENT MEDICAL THERAPY OF PANCREATITIS. Med Clin North Am. 1964 Mar;48:389–397. doi: 10.1016/s0025-7125(16)33471-x. [DOI] [PubMed] [Google Scholar]
  14. Nakajima S., Magee D. F. Inhibition of exocrine pancreatic secretion by glucagon and D-glucose given intravenously. Can J Physiol Pharmacol. 1970 May;48(5):299–305. doi: 10.1139/y70-049. [DOI] [PubMed] [Google Scholar]
  15. PAPASTRAT C. J., MILLER J. M. Treatment of external pancreatic fistula with diamox; report of a case. Am J Dig Dis. 1958 May;3(5):399–407. doi: 10.1007/BF02232404. [DOI] [PubMed] [Google Scholar]
  16. Ranson J. H., Rifkind K. M., Roses D. F., Fink S. D., Eng K., Spencer F. C. Prognostic signs and the role of operative management in acute pancreatitis. Surg Gynecol Obstet. 1974 Jul;139(1):69–81. [PubMed] [Google Scholar]
  17. Ryan J. A., Jr, Abel R. M., Abbott W. M., Hopkins C. C., Chesney T. M., Colley R., Phillips K., Fischer J. E. Catheter complications in total parenteral nutrition. A prospective study of 200 consecutive patients. N Engl J Med. 1974 Apr 4;290(14):757–761. doi: 10.1056/NEJM197404042901401. [DOI] [PubMed] [Google Scholar]
  18. SHAPER A. G. Chronic pancreatic disease and protein malnutrition. Lancet. 1960 Jun 4;1(7136):1223–1224. doi: 10.1016/s0140-6736(60)91103-x. [DOI] [PubMed] [Google Scholar]
  19. Smith R. Progress in the surgical treatment of pancreatic disease. Am J Surg. 1973 Feb;125(2):143–153. doi: 10.1016/0002-9610(73)90019-6. [DOI] [PubMed] [Google Scholar]
  20. Trapnell J. E., Rigby C. C., Talbot C. H., Duncan E. H. A controlled trial of Trasylol in the treatment of acute pancreatitis. Br J Surg. 1974 Mar;61(3):177–182. doi: 10.1002/bjs.1800610303. [DOI] [PubMed] [Google Scholar]
  21. Warshaw A. L., Fuller A. F., Jr Specificity of increased renal clearance of amylase in diagnosis of acute pancreatitis. N Engl J Med. 1975 Feb 13;292(7):325–328. doi: 10.1056/NEJM197502132920701. [DOI] [PubMed] [Google Scholar]

Articles from Annals of Surgery are provided here courtesy of Lippincott, Williams, and Wilkins

RESOURCES