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. 1977 Nov;186(5):614–618. doi: 10.1097/00000658-197711000-00012

Release of antral and duodenal gastrin in response to an intestinal meal.

O L Llanos, H V Villar, S J Konturek, P L Rayford, J C Thompson
PMCID: PMC1396321  PMID: 21638

Abstract

In dogs prepared with isolated, innervated antral pouches, intraduodenal perfusion with liver extract at pH 7, with the atrum buffered at pH 7, resulted in a significant release of gastrin selectively from the antrum and from the duodenum. Acidification of the meal to pH 1 abolished both antral and duodenal gastrin release, whereas acidification of the antrum abolished only the antral gastrin response. After antrectomy, liver extract at pH 7 caused a diminished but significant release of duodenal gastrin. These studies provide evidence that an intestinal meal may release (in addition to a specific intestinal phase hormone) gastrin from the intestine, and from antrum, by means of a pH-sensitive mechanism which may involve a humoral agent (enterobombesin?) from the small bowel.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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