TABLE 2.

Comparison of geometric mean neutralizing antibody responses of sheep, goats, and cattle to quadrivalent FMD vaccines formulated with ISA 206 adjuvant^a

FMDV serotype	Period (days)	ISA 206		P value (sheep vs goats)	ISA206 (Cattle)	P value (sheep vs cattle)
		Sheep	Goats
O	30	2.21	1.44	0.002b	2.62	0.02b
	60	3.33	1.8	<0.0001b	3.15	0.44
	90	3.52	2.76	0.001b	3.45	0.06
A	30	2.15	2.34	0.25	2.62	0.003b
	60	2.64	2.76	0.39	3	0.006b
	90	3.62	2.94	<0.0001b	3.37	0.01b
C	30	2.12	2.02	0.35	2.52	0.0001b
	60	2.54	2.55	0.56	3.15	0.006b
	90	3.45	3	0.008b	3.37	0.3
Asia-1	30	2.22	2.1	0.79	2.55	0.01b
	60	2.60	2.63	0.76	3.15	0.01b
	90	3.40	3.22	0.08	3.3	0.84

^aSix serum samples were collected at 30, 60, and 90 dpv. Virus-neutralizing antibody titers were measured by microneutralization test. The neutralizing antibody titer of the serum was expressed as the reciprocal of the dilution that neutralized 50% of the virus. The values shown are geometric mean titers expressed in log₁₀, and statistical significance was determined by unpaired Student t test.

^bP < 0.05.