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. 2002 Jan;22(2):644–656. doi: 10.1128/MCB.22.2.644-656.2002

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Copyright © 2002, American Society for Microbiology

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FIG. 6. — Increased spontaneous tumor incidence in Cdk4^R24C/R24C mice. (a) Kaplan-Meier survival curves of Cdk4^+/+ (n = 21) (+/+), Cdk4^+/R24C (n = 31) (+/R24C), and Cdk4^R24C/R24C (n = 34) (R24C/R24C) mice that were observed for 20 months for the appearance of detectable or palpable tumors. Tumor-prone mice were euthanized, and tumors were dissected and processed for histological analysis. (b to e) Histological analysis of spontaneous mammary and pituitary tumors and melanomas in Cdk4^R24C/R24C mice. Photomicrographs of three tumor types are presented. (b) Cdk4^R24C/R24C mice are susceptible to increased mammary tumorigenesis with severe tumor burden. (c) Mammary tumors are either mammary adenocarcinomas or adenocanthomas with squamous differentiation and keratinization (indicated by arrows). (d) Cdk4^R24C/R24C mice are susceptible to increased incidence of pituitary tumorigenesis either in the pars distalis or pars intermedia with characteristic blood-filled lakes (indicated by arrows). (e) Cdk4^R24C/R24C mice also present a low incidence of melanoma occurrence with pigment granules and cells loaded with pigment (indicated by arrows).

FIG. 6. — Increased spontaneous tumor incidence in Cdk4^R24C/R24C mice. (a) Kaplan-Meier survival curves of Cdk4^+/+ (n = 21) (+/+), Cdk4^+/R24C (n = 31) (+/R24C), and Cdk4^R24C/R24C (n = 34) (R24C/R24C) mice that were observed for 20 months for the appearance of detectable or palpable tumors. Tumor-prone mice were euthanized, and tumors were dissected and processed for histological analysis. (b to e) Histological analysis of spontaneous mammary and pituitary tumors and melanomas in Cdk4^R24C/R24C mice. Photomicrographs of three tumor types are presented. (b) Cdk4^R24C/R24C mice are susceptible to increased mammary tumorigenesis with severe tumor burden. (c) Mammary tumors are either mammary adenocarcinomas or adenocanthomas with squamous differentiation and keratinization (indicated by arrows). (d) Cdk4^R24C/R24C mice are susceptible to increased incidence of pituitary tumorigenesis either in the pars distalis or pars intermedia with characteristic blood-filled lakes (indicated by arrows). (e) Cdk4^R24C/R24C mice also present a low incidence of melanoma occurrence with pigment granules and cells loaded with pigment (indicated by arrows).