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. 2002 Jul;22(14):5100–5113. doi: 10.1128/MCB.22.14.5100-5113.2002

FIG.3.

FIG.3.

LacZ reporter expression during embryonic development of GFAP-Cre transgenic mice. β-Galactosidase activity was detected by embryonic day 14.5 in the brain of the GFAP-Cre transgenic mice. In E18.5 GFAP-Cre embryos, robust LacZ activity is detected in the brain, spinal cord, and optic nerves. No LacZ expression is observed in a control littermate (E18.5 control). The intestines of both GFAP-Cre and control mice show endogenous LacZ activity. Mouse embryos were photographed at ×8 magnification at E11.5 and E13.5, ×5 magnification at E15.5, and ×3 magnification at E18.5.