TABLE 1.
ECG parameters in anesthetized micea
| Genotype | HR (bpm) | QT (ms) | QTc (ms) | QTVIb | HRP (ms2)c | LF/HF HRVc |
|---|---|---|---|---|---|---|
| Wild type (n = 28) | 456 ± 8.3 | 74 ± 1.3 | 64.2 ± 1.13 | −0.39 ± 0.176 | 31.7 ± 6.11 | 1.16 ± 0.166 |
| Nhlh1−/− (n = 23) | 447 ± 8.4 | 75 ± 1.0 | 64.6 ± 0.87 | 0.17 ± 0.142d | 14.2 ± 1.96d | 2.23 ± 0.653 |
| KH (n = 27) | 489 ± 9.2 | 76 ± 1.7 | 68.2 ± 1.55 | 0.42 ± 0.148e | 17.2 ± 3.26d | 3.77 ± 0.833d |
a
Figures are means ± standard errors of the mean. HR, heart rate; QT, QT interval; QTc, adjusted QT interval; HRP, heart rate power; LF/HR HRV, low-frequency-to-high-frequency heart rate variability ratio.
b
Statistical significance, by analysis of variance: P < 0.001.
c
Statistical significance, by analysis of variance: P < 0.05.
d
P < 0.05 compared to the wild type, by Dunnett's multiple-comparison test.
e
P < 0.01 compared to the wild type, by Dunnett's multiple-comparison test.