Table 1.
Selected studies exploring the relation of multiple sclerosis with human herpes virus-6
Material used | Method followed | Relation to MS | Year of publication |
Brain tissue | Viral DNA-PCR, immunohistochemistry | Positive | 1995[44] |
Viral DNA-PCR | Negative | 1996[49] | |
Viral DNA-PCR, immunohistochemistry | Positive | 1999[47] | |
Immunohistochemistry | Positive | 2000[58] | |
Viral DNA-PCR | Positive | 2000[59] | |
Viral DNA-PCR, immunohistochemistry | Positive | 2003[60] | |
Viral DNA-PCR | Uncertain | 2003[48] | |
CSF | Viral DNA-PCR | Negative | 1999[50] |
Viral DNA-PCR, antibodies titer | Negative | 2000[51] | |
Viral DNA-PCR, antibodies titer | Positive | 2002[52] | |
Serum | Viral DNA-PCR | Negative | 1999[50] |
Viral DNA-PCR, antibodies titer | Positive | 2000[52] | |
Viral DNA-PCR | Positive | 2000[53] | |
Viral DNA-PCR | Positive | 2001[54] | |
Viral DNA-PCR | Negative | 2002[55] | |
Viral DNA-PCR, antibodies titer | Positive | 2003[56] | |
Peripheral blood mononuclear cells | Viral DNA-PCR | Negative | 2000[51] |
Viral DNA-PCR | Positive | 2000[53] | |
Viral DNA-PCR | Negative | 2000[57] | |
Viral DNA-PCR | Positive | 2001[54] | |
Viral DNA-PCR | Positive | 2002[55] | |
Viral DNA-PCR | Positive | 2003[56] |