TABLE 2.
Culture of bone marrow cells
| Stimulus | Genotype | No. of coloniesa
|
|||||
|---|---|---|---|---|---|---|---|
| Blast | G | GM | M | Eo | Meg | ||
| GM-CSF | Tssc6+/+ | 0 | 18 | 9 | 17 | 3 | 0 |
| Tssc6gt/gt | 0 | 19 | 6 | 21 | 0 | 0 | |
| G-CSF | Tssc6+/+ | 0 | 10 | 0 | 0 | 0 | 0 |
| Tssc6gt/gt | 0 | 12 | 1 | 0 | 0 | 0 | |
| M-CSF | Tssc6+/+ | 0 | 3 | 5 | 35 | 0 | 0 |
| Tssc6gt/gt | 0 | 1 | 1 | 34 | 0 | 0 | |
| IL-3 | Tssc6+/+ | 8 | 17 | 14 | 19 | 4 | 8 |
| Tssc6gt/gt | 3 | 26 | 12 | 18 | 6 | 3 | |
| SCF | Tssc6+/+ | 12 | 27 | 1 | 0 | 0 | 0 |
| Tssc6gt/gt | 5 | 18 | 0 | 1 | 0 | 0 | |
| TPO | Tssc6+/+ | 0 | 0 | 0 | 0 | 0 | 5 |
| Tssc6gt/gt | 0 | 0 | 0 | 0 | 0 | 3 | |
a
Total numbers of colonies present in stained cultures of 25,000 cells. Representative data from one of three comparable experiments are given. G, granulocyte; GM, granulocyte-macrophage; M, macrophage; Eo, eosinophil; Meg, megakaryocyte.