FIG. 1.
Schematic representation of Grb14 and ZIP proteins. (A) Grb14. Shown are the proline-rich motif (PP); the PH domain; the PIR (28), also called BPS, between the PH and SH2 domain (22); and the SH2 domain. (B) ZIP and various ZIP constructs. The arrow indicates the length of the ZIP protein isolated in the two-hybrid screen. Shown are the AID (47), ZZ, PEST sequences (PEST2 is lacking in the ZIPβ isoform), and ubiquitin-associated (UBA) domain (70).