FIG. 4.

The alignment of the amino termini of p53, TAp63, and TAp73 is shown above the domain structure model. The alignment of TI domains of p63α and p73α is shown below. The three conserved residues important for p53 binding to MDM2 and transcriptional cofactors are highlighted as white on dark gray. Asterisks indicate p53 residues shown to be phosphorylated under certain conditions. The SUMO-1-modified lysine is highlighted as white on dark gray. Triangles indicate truncation points at the N and C termini used in assays depicted in Fig. 3 and 6.