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. 2002 Dec;22(24):8626–8634. doi: 10.1128/MCB.22.24.8626-8634.2002

FIG. 2.

FIG. 2.

Defective spleen organization in TNF/LTΔ3 mice. Magnifications are given on left. (A) Splenic cryosections of 6- to 8-week-old mice immunized with SRBC were stained to detect the distribution of T cells (CD3, blue) and B cells (IgD [brown], IgM), FDC (CR1), or stromal elements (ER-TR7) in TNF/LTΔ3 and single-knockout mice. WT, wild type. (B) Side-by-side comparison with TNF/LTα−/− mice. Splenic cryosections of 6- to 8-week-old nonimmunized mice were stained with anti-CD3 (blue), anti-B220 (brown), or anti-ER-TR7.