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EBF/O/E-1 is a central transcriptional regulator in the developing B lymphocyte. The figure displays the suggested functional relationships between the transcription factors E2A, O/E-1, and Pax-5. Suggested target genes are located under the transcription factors and common target genes are indicated by arrows. The flow and stage of B-cell development are indicated in the right part of the figure by a broad shaded arrow.
