TABLE 2.
In vitro colony formation by bone marrow hematopoietic progenitors from wild-type and p110δ-deficient mice in response to various cytokines
| Mice | Colony formationa in response to:
|
|||||||
|---|---|---|---|---|---|---|---|---|
| Epo + IL-3 (BFU-E) | IL-3 (CFU-Mix) | IL-9 (CFU-Eos) | IL-7 (pre-B) | Tpo (CFU-Meg) | G-CSF (CFU-G) | GM-CSF (CFU-GM) | CSF-1 (CFU-M) | |
| p110δ+/+ | 3.3 ± 0.8 | 24 ± 10 | 12.2 ± 2.5 | 52 ± 11 | 2.6 ± 0.6 | 74 ± 15 | 347 ± 30 | 351 ± 63 |
| p110δ−/− | 2.6 ± 0.7 | 20 ± 11 | 7.3 ± 1.6 | 47 ± 13 | 2.7 ± 0.7 | 72 ± 8 | 361 ± 21 | 406 ± 39 |
a
Mean number of colonies ± standard deviation per 2 × 105 cells (BFU-E and CFU-Eos), 1.5 × 104 cells (CFU-Mix and CFU-GM), 5 × 104 cells (pre-B, CFU-G, and CFU-M), or 4 × 105 cells (CFU-Meg).