Table 1.

TTR homotetramer dissociation rates derived from time courses as a function of urea concentration extrapolated to 0 M urea concentration

Sequence	kdiss*, h−1	mkin*, M−1
WT	1.68  ± 0.15⋅10−2	0.094  ± 0.013
V30M	1.02  ± 0.37⋅10−2	0.121  ± 0.066
L55P	15.7  ± 0.58⋅10−2	0.179  ± 0.008
V122I	3.64  ± 0.38⋅10−2	0.100  ± 0.02
T119M	4.52  ± 1.18⋅10−4	0.303  ± 0.03

^*k_diss is the tetramer dissociation rate constant, and m^kin is the urea dependence of the tetramer dissociation rate constant.