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The ends of the open β-globin domain. (A) 3′end. A second constitutive HS that binds CTCF and has enhancer blocking activity is found upstream of the beginning of a condensed chromatin region containing a gene for an odorant receptor (8). (B) 5′ end. A condensed chromatin region extends for about 16 kb upstream of 5′HS4, and beyond that is an erythroid-specific FR gene (9).
