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Sequence comparison of Lrp binding sites. The consensus Lrp binding sequence as determined by selex (43) is shown on the bottom line (Y = C or T, H = not G, W = A or T, D = not C, R = A or G). Lrp binding sites 1 through 6 of pap and ilvIH binding site 2 are shown above the selex sequence. The abilities of PapI to increase the affinity of Lrp for each site is shown at the far right, where “Yes” indicates an increase in Lrp affinity.
