Table 5.

Marginal model and random-effects models analysing the influence of time and age

	Marginal model GEE			Random model likelihood integration
	Estimate	SE	p value	Estimate	SE	p value
Intercept	-1.83	0.12	< 0.0001	-3.61	0.25	< 0.0001
Time (years)	0.12	0.03	< 0.0001	0.17	0.06	0.002
Age at baseline*	0.09	0.02	< 0.0001	0.16	0.03	< 0.0001
Age* × time	0.01	0.004	0.003	0.04	0.009	< 0.0001
Baseline disability	1.54	0.10	< 0.0001	3.18	0.22	< 0.0001
Death during the study	0.68	0.12	< 0.0001	1.36	0.26	< 0.0001
Random intercept variance	-	-	-	7.25	0.68	< 0.0001
Random slope variance	-	-	-	0.18	0.04	< 0.0001