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Alignment of the amino acid sequences surrounding Ser165 of topo IIβ. Conserved residues are indicated in bold. Asterisks indicate residues in E.coli gyr B which make hydrogen bonds to AMPPNP: Lys103, Tyr109, Leu115, His116, Val118 and Gly119. The box includes residues of the highly conserved glycine loop, Gly114, Gly117 and Gly119.
