TABLE 2.

Mouse SAP and SAA Values in Wild Type and Human CRP Transgenic Mice

Age	12 months			14 months			16 months			18 months
Protein (mg/L)	CRP	SAP	SAA	CRP	SAP	SAA	CRP	SAP	SAA	CRP	SAP	SAA
Wild type (n=7)
Median	0	6.3	6.7	0	4.2	NA	0	7.1	NA	0	8.9	12.5
Range	0-0	5.7-11.9	4.2-16.6	0-0		3.0-8.9	0-0	5.2-18.0		0-0	6.0-35.1	10.7-171.0
hCRP transgenic (n=10)
Median	2.4	7.0	7.6	4.9	5.2	NA	1.5	7.1	NA	2.8	8.0	20.4
Range	0.7-9.1	5.2-10.3	1.4-16.2	1.9-79.3	3.6-90.2		0.7-10.2	4.1-12.7		0.8-14.2	5.3-47.9	10.7-141.7

NA, not assayed.

There were no significant differences between wild type and human CRP transgenic mice with respect to SAP and SAA concentrations at any time point; range of P values (Mann Whitney U test) at various ages, 0.52-0.77.