Fig. 6. Ligand-selective stimulation of AR transcriptional activity by PRK. (A) Super-activation of the AR by PRK1 signalling in the presence of adrenal androgens. 293 cells were co-transfected with AR and MMTV-LUC in the presence or absence of the indicated androgens. (B) PRK signalling activates the AR in the presence of the anti-androgen CPA. DU145 cells were stimulated with or without 10^–5 M CPA and co-transfected with the indicated expression plasmids.