Table 1.

The ratio of n-3 to n-6 fatty acids in the microsomal or mitochondrial membranes of liver, colon or tumor in mice fed a diet containing either 5% corn oil (CO) or 3% fish oil concentrate (FOC) and 2% CO with or without 2000 IU/kg Vitamin E for two weeks. Two way ANOVA revealed that consumption of supplemental Vitamin E did not effect the fatty acid composition thus ratios due to dietary fat are shown. Mean ± SEM, (n).

Tissue	Fraction	5% CO	3% FOC/2% COa	Fold difference
Liver	Microsomal	0.06 ± 0.02 (8)	1.11 ± 0.18 (7)	18.5
	Mitochondrial	0.09 ± 0.02 (8)	0.77 ± 0.08 (7)	8.6
Colon	Microsomal	0.18 ± 0.09 (8)	0.62 ± 0.15 (7)	3.4
	Mitochondrial	0.24 ± 0.09 (8)	0.59 ± 0.24 (7)	2.5
Tumor	Microsomal	0.11 ± 0.10 (8)	1.15 ± 0.10 (7)	10.5
	Mitochondrial	0.59 ± 0.57 (8)	1.32 ± 0.37 (7)	2.2

^a The n-3 to n-6 ratio was significantly higher in every tissue fraction of mice that consumed the FOC diet than in mice that consumed the CO diet.