Table 2.

Total distribution of resistance-associated mutations and wild type among imported isolates of P. falciparum in Europe

Resistance to	Gene locus	Mutation (%)	Wild type (%)	Total
Chloroquine	Pfcrt 76	204 (68.2%)	95 (31.8%)	299
	Pfmdr 86	85 (42.3%)	116 (57.7%)	201
Group I antifolates	DHFR 51	135 (44.3%)	170 (55.7%)	305
	DHFR 108	170 (58.4%)	121 (41.6%)	291
	DHFR 59	156 (55.1%)	127 (44.9%)	283
Group II antifolates	DHPS 436	79 (33.3%)	158 (66.7%)	237
	DHPS 437	92 (40.4%)	136 (59.6%)	228
	DHPS 540	12 (5.3%)	216 (94.7%)	228
	DHPS 581	6 (2.3%)	255 (97.7%)	261

Group I antifolates: e.g. pyrimethamine. Group II antifolates: sulfonamides DHFR = dihydrofolate reductase DHPS = dihydropteroate synthetase