Skip to main content
. 2006 Mar 17;2(3):e21. doi: 10.1371/journal.ppat.0020021

Figure 3. The Core Set of C. albicans Caspofungin-Responsive Genes.

Figure 3

The expression profiles of 34 caspofungin-responsive genes that (i) exhibited a 2-fold change (p < 0.05) in response to caspofungin treatment in our experiments (Dataset S1) and (ii) exhibited a corresponding increase or decrease in response to caspofungin in the report by Liu et al. [7]. “Gene symbol” refers to entries in CGD. The columns “wt−/wt+,” “ada2/wt+,” “cas5/wt+,” and “rlm1/wt+” summarize the response of each gene in microarray comparisons of the untreated wild-type strain, the treated Caada2Δ/Δ strain, the treated Cacas5Δ/Δ strain, and the treated Carlm1Δ/Δ strain, each compared to the treated wild-type strain, respectively. Green color indicates a higher level of expression in the treated wild-type strain; red color indicates a lower level of expression in the treated wild-type strain. The degree of color saturation represents the magnitude of the expression ratio, which may be found in Dataset S1. The columns “motif 5” and “motif 3” refer to presence of the nucleotide sequences GTGGYSYKGKKG and WTGWTRWTGWTGWKSYKGW, respectively, within 999 bp of each gene's 5′ region; blue color indicates presence of the sequence. The motifs were identified through MEME analysis of CaCas5-dependent gene 5′ regions. Among noncore gene 5′ regions, motif 5 was also associated with orf19.7350, orf19.6595, orf19.753, and orf19.4771; motif 3 was also associated with orf19.13071, orf19.6595, orf19.753, orf19.7350, orf19.4771, and orf19.711.