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. 2006 Mar 17;2(3):e35. doi: 10.1371/journal.pgen.0020035

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© 2006 Gatbonton et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Telomerase is required for increased telomere length in long telomere mutants. This shows telomere length of single tlc1, tlm, and double tlc1 tlm mutants 20 doublings after germination of TLC1/tlc1 TML/tlm heterozygous diploids. Telomere length of double tlc1 tlm mutants is similar to telomere length of tlc1 single mutants.

(B) VPS genes and NMD genes participate in separate telomere-maintenance pathways. VSP genes (e.g., VPS34, VPS15) are epistatic with KU telomere-capping pathway (e.g., YKU70), and NMD genes (e.g., NAM7) have synthetic telomere phenotype with the lack of YKU70.