Table 1.
Biological functions of representative genes detected in this work
| Gene symbol | Aliases | Regulation | Description | Reference |
|---|---|---|---|---|
| ALK | – | Up | Having oncogenetic roles of haematopoietic and non-haematopoietic tumors | Pulford et al. (25) |
| BCL10 | Bcl10 | Up | Activation of NF-κB cascade through ubiquitination of NEMO | Zhou et al. (26) |
| ERN1 | IRE1 | Up | Mediating endoplasmic reticulum stress-induced NF-κB activation | Kaneko et al. (27) |
| MTCP1 | MTCP-1 | Up | A candidate gene potentially involved in the leukemogenic process of mature T cell proliferations | Stern et al. (28) |
| SAFB | SAFB1 | Up | A repressor of ERα activity via indirect association with histone deacetylation | Townson et al. (29) |
| ASRGL1 | hALP | Up | A transactivator of telomerase activity | Lv et al. (30) |
| DHX9 | RHA | Up | A component of the transactivation complex for the transcriptional activity of NF-κB | Tetsuka et al. (31) |
| STAG1 | – | Up | A transcriptional target for p53 and a mediator of p53-dependent apoptosis | Anazawa et al. (32) |
| CDK5R1 | p35, p25 | Up | A mediator of apoptosis in digoxin-triggered prostate cancer cell | Lin et al. (33) |
| RASSF1 | RASSF1A | Down | DNA methylation of RASSF1 promortor is associated with poor outcome of breast cancer | Müller et al. (34) |
| SRA1 | SRA | Down | A coactivator of ERα transcriptional activity | Cavarretta et al. (35) |
| TNFSF12 | TWEAK | Down | Inducing multiple pathways of cell death | Nakayama et al. (36) |
| CST3 | CystC | Down | Inhibiting the invasion of breast cancer cell | Sokol et al. (37) |
| EGR3 | – | Down | A target for transcriptional factor ERα | Inoue et al. (38) |
| CCNL2 | Cyclin L2 | Down | A regulator of the transcription and RNA processing of certain apoptosis-related factors | Yang et al. (39) |
| SEPW1 | – | Down | Allelic loss of the chromosome 19q arm is a frequent event in human diffuse gliomas | Smith et al. (40) |
| SYNPO2 | Myopodin | Down | A tumor suppressor gene to limit the growth and to inhibit the metastasis of cancer cells | Jing et al. (41) |
| ZDHHC13 | FLJ10852 | Down | Forced expression of ZDHHC13 activates the NF-κB signaling pathway | Matsuda et al. (42) |
Gene symbol, representative gene symbol of the candidate gene; aliases, other names of the gene or its product in references; regulation, ‘up’ or ‘down’ indicates the gene regulation detected in poor prognosis patient group by our method.