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. 1981 Aug;12(2):223–228. doi: 10.1111/j.1365-2125.1981.tb01204.x

Once daily beta-adrenoceptor blockade in hypertension: an ambulatory assessment.

S Mann, M W Craig, V Balasubramanian, E B Raftery
PMCID: PMC1401861  PMID: 6118172

Abstract

1 The ambulant intra-arterial blood pressure of eighteen hypertensive subjects was monitored before and again after 3 months treatment with thrice daily sotalol (six patients), twice daily pindolol (six patients) and once daily pindolol (six patients). 2 Three patients in the sotalol group underwent a third study having changed to a once daily regimen; similarly six patients in the pindolol groups were restudied having crossed over to the alternative pindolol dosing regimen, total daily dosage being maintained in all cases. 3 Comparison of 24 h blood pressure curves before and after treatment showed effective daytime reduction but less consistent effects at night. 4 In the crossover experiments once daily and multiple daily dosing regimens produced identical patterns of reduction over 24 h in both blood pressure and heart rate. 5 It is inferred that in the treatment of hypertension, once daily dosing with standard preparations of beta-adrenoceptor blocking agents is probable adequate.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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