Table I. γ gene expressiona in the –198 HPFH transgenic mice.
| Construct | Line | Copy no. | Embryonic (primitive) erythropoiesis |
Definitive erythropoiesis |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Day 10b |
Day 12b |
Day 12b |
Day 16b |
Adult |
||||||
| Blood | Yolk sac | Blood | Yolk sac | Liver | Blood | Liver | Blood | |||
| µLCR –382Aγ | A | 5 | 6.9 ± 0.9 | 10.2 ± 1.1 | 21.6 ± 4.9 | 30.1 ± 4.7 | 23.7 ± 3.0 | 11.7 ± 0.8 | 12.4 ± 1.0 | 16.9 ± 1.1 |
| with –198 HPFH | B | 4 | 9.3 ± 0.3 | 10.7 ± 3.9 | 16.2 ± 4.0 | 30.5 ± 5.8 | 25.9 ± 2.8 | 19.8 ± 3.6 | 20.7 ± 2.3 | 15.1 ± 1.7 |
| mean | 8.1 | 10.5 | 18.9 | 30.3 | 24.8 | 15.8 | 16.6 | 16.0 | ||
| µLCR –382Aγ ΔCACCC | C | 12 | 7.6 ± 1.1 | 13.6 ± 1.3 | 28.6 ± 7.7 | 67.4 ± 14.5 | 30.1 ± 1.8 | 8.6 ± 0.9 | 10.2 ± 0.2 | 7.9 ± 1.5 |
| with –198 HPFH | D | 13 | 7.2 ± 0.5 | 10.4 ± 1.3 | 20.0 ± 3.7 | 51.6 ± 5.4 | 18.9 ± 2.8 | 11.9 ± 3.3 | 17.3 ± 5.2 | 13.8 ± 2.4 |
| E | 10 | 10.6 ± 0.6 | 19.1 ± 4.5 | 16.0 ± 1.1 | 69.7 ± 13.8 | 19.7 ± 1.3 | 11.9 ± 1.4 | 13.8 ± 1.7 | 10.4 ± 1.3 | |
| mean | 8.5 ± 1.9 | 14.4 ± 4.4 | 21.5 ± 6.4 | 62.9 ± 9.9 | 22.9 ± 6.2 | 10.8 ± 1.9 | 13.8 ± 3.6 | 10.7 ± 3.0 | ||
| µLCR –382Aγ | mean | 5.7 ± 6.3 | 5.2 ± 3.3 | 10.4 ± 9.5 | 21.0 ± 7.4 | 11.8 ± 2.8 | 13.4 ± 4.7 | 15.7 ± 4.8 | 16.5 ± 4.5 | |
| µLCR –382Aγ ΔCACCC | mean | 4.2 ± 0.6 | 6.1 ± 1.7 | 8.9 ± 4.3 | 13.9 ± 3.9 | 5.2 ± 3.0 | 2.9 ± 1.3 | 2.6 ± 0.9 | 0.9 ± 0.6 | |
aHuman γ mRNA is expressed as a percentage of murine α mRNA per copy. Mean values are shown in bold. Data in µLCR –382Aγ control mice are from Stamatoyannopoulos et al. (1993).
bDays post-coitus.