Table III. γ gene expressiona in the –117 HPFH transgenic mice.
| Construct | Line | Copy no. | Embryonic (primitive) erythropoiesis |
Definitive erythropoiesis |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Day 10b |
Day 12b |
Day 12b |
Day 16b |
Adult |
||||||
| Blood | Yolk sac | Blood | Yolk sac | Liver | Blood | Liver | Blood | |||
| µLCR –141Aγ | P | 8 | 6.0 ± 0.5 | 11.3 ± 0.7 | 10.4 | 14.9 | 10.0 | 11.5 ± 2.7 | 11.3 ± 3.6 | 6.4 ± 1.4 |
| with –117 HPFH | Q | 36 | 7.5 ± 0.8 | 11.3 ± 1.8 | 14.9 ± 1.0 | 24.0 ± 6.5 | 9.8 ± 1.2 | 14.4 ± 3.2 | 7.4 ± 0.3 | 5.3 ± 1.0 |
| R | 33 | 5.6 ± 0.9 | 12.4 ± 3.3 | 10.5 ± 1.8 | 17.7 ± 2.5 | 11.7 ± 0.6 | 7.9 ± 0.5 | 13.0 ± 2.4 | 6.7 ± 1.3 | |
| S | 22 | 8.5 ± 2.1 | 14.2 ± 1.5 | 15.0 ± 2.2 | 19.8 ± 4.4 | 11.7 ± 1.6 | 8.3 ± 1.5 | 8.2 ± 2.4 | 6.6 ± 0.5 | |
| mean | 6.9 ± 1.3 | 12.3 ± 1.4 | 12.9 ± 2.9 | 19.1 ± 3.8 | 10.8 ± 1.0 | 10.5 ± 3.0 | 10.0 ± 2.6 | 6.3 ± 0.6 | ||
| µLCR –141Aγ | mean | 2.4 ± 1.0 | 4.9 ± 1.0 | 10.6 ± 4.3 | 11.6 ± 2.1 | 4.3 ± 2.3 | 0.5 ± 0.3 | |||
aHuman γ mRNA is expressed as a percentage of murine α mRNA per copy. Mean values are shown in bold. Data in µLCR –141Aγ control mice are from Stamatoyannopoulos et al. (1993).
bDays post-coitus.