Abstract
1 In an open, randomized cross-over investigation of thirteen patients (nine and four women, aged 37-67 years) with mild or moderate essential hypertension a comparison between atenolol and metoprolol was carried out in order to study the effects of 50, 100 and 200 mg given once daily on blood pressure and heart rate at rest and during exercise. 2 Before one beta-adrenoceptor blocking drug was replaced by the other in a patient an intervening drug-free interval of sufficient length was secured to allow an increase in the blood pressure to pretreatment levels. 3 A maximal fall in blood pressure was achieve with 50 mg atenolol once daily, with no further reduction when the dose was increased to 100 mg or 200 mg. Maximal blood pressure reduction was achieved with 100 mg metoprolol daily, while the hypertensive effect of 50 mg once daily was not consistent. Significant reductions in heart rate in all test situations were observed with 50 mg atenolol, while 200 mg metoprolol 100 was necessary to reduce exercise-induced tachycardia. 4 Atenolol 50 mg and metoprolol 100 mg once daily are efficient in treating mild or moderate hypertension and doses beyond these may not reduce the blood pressure further. On the contrary lower doses than generally recommended may be effective in the individual patient.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Barber J. H. Relative activity of atenolol and metoprolol. Br Med J. 1978 Jul 29;2(6133):357–357. doi: 10.1136/bmj.2.6133.357-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Comerford M. B., Besterman E. M. Relative activity of atenolol and metoprolol. Br Med J. 1977 Jul 23;2(6081):260–260. doi: 10.1136/bmj.2.6081.260. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Comerford M. B., Besterman E. Dosing intervals in beta-blocker therapy. Lancet. 1980 Nov 29;2(8205):1196–1196. doi: 10.1016/s0140-6736(80)92629-x. [DOI] [PubMed] [Google Scholar]
- Douglas-Jones A. P., Cruickshank J. M. Once-daily dosing with Atenolol in patients with mild or moderate hypertension. Br Med J. 1976 Apr 24;1(6016):990–991. doi: 10.1136/bmj.1.6016.990. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jeffers T. A., Webster J., Petrie J. C., Barker N. P. Atenolol once-daily in hypertension. Br J Clin Pharmacol. 1977 Oct;4(5):523–527. doi: 10.1111/j.1365-2125.1977.tb00780.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jeffers T. A., Webster J., Reid B., Petrie J. C., Barker N. P. Atenolol and metoprolol in mild hypertension. Br Med J. 1978 Nov 4;2(6147):1269–1269. doi: 10.1136/bmj.2.6147.1269. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Karlberg B. E., Nilsson O., Tolagen K., Nitelius E., Waern U. Once-daily metoprolol in primary hypertension. Clin Pharmacol Ther. 1979 Apr;25(4):399–407. doi: 10.1002/cpt1979254399. [DOI] [PubMed] [Google Scholar]
- Lyngstam O., Rydén L. Metoprolol and atenolol administered once daily in primary hypertension. A clinical comparison of the efficacy of two selective beta-adrenoceptor blocking agents. Acta Med Scand. 1981;209(4):261–266. [PubMed] [Google Scholar]
- Marshall A. J., Barritt D. W., Heaton S., Harry J. D. Dose response for blood pressure and degree of cardiac beta-blockade with atenolol. Postgrad Med J. 1979 Sep;55(646):537–540. doi: 10.1136/pgmj.55.646.537. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Nilsson O. R., Karlberg B. E., Ohlsson O., Thulin T., Tolagen K. Atenolol administered once daily in primary hypertension. Effects on blood pressure in relation to pre-treatment plasma renin activity. Acta Med Scand. 1979;206(4):303–308. [PubMed] [Google Scholar]
- Reybrouck T., Amery A., Fagard R., Jousten P., Lijnen P., Meulepas E. Beta-blockers: once or three times a day? Br Med J. 1978 May 27;1(6124):1386–1388. doi: 10.1136/bmj.1.6124.1386. [DOI] [PMC free article] [PubMed] [Google Scholar]
- de Nollin S., Borgers M. The effects of miconazole on the ultrastructure of Candida albicans. Proc R Soc Med. 1977;70 (Suppl 1):9–12. doi: 10.1177/00359157770700S104. [DOI] [PMC free article] [PubMed] [Google Scholar]