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. 2003 Dec 23;1:e012. doi: 10.1621/nrs.01012

Figure 6. Typical experiment in which wild-type male mice were treated with several different nuclear receptor agonists.

Figure 6

The relative changes in mRNA expression for known receptor target genes, in this case SREBP-1c, an LXR target gene, were measured using the comparative Ct method. (a) SREBP-1c expression plotted for each of the animals (S.D. Each color represents a different experimental group (n=4 animals). (b) SREBP-1c expression plotted as averages of the fold changes for the 4 animals in each treatment group shown in (a) (SEM. Note that the SREBP-1c transcript increases relative to control (VEH) in the animals treated with an RXR agonist (LG268), an LXR agonist (T1317), or both LG269 and T1317 together (T+LG). Note that ligands for PPAR- α (fenofibrate), PPAR- γ (troglitazone), FXR (CDCA), PXR (PCN), and CAR (TCPOBOB) have no effect on the level of the SREBP-1c message relative to control.