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. 2003 Jun 27;1:e006. doi: 10.1621/nrs.01006

Figure 2. Physiological effects of PPAR-γ activation.

Figure 2

PPAR-γ induces adipocyte differentiation and genes involved in fat deposition. Plasma-derived fatty acids are directed to adipose tissue at the expense of skeletal muscle, which increases glucose uptake and utilization in the muscle. Direct effects of PPAR-γ activation have also been observed in liver, including decreased gluconeogenesis and increased fat uptake and storage. Additionally, PPAR-γ activation results in increased cholesterol efflux in macrophages via upregulation of ABCA1, but also increased uptake of proatherogenic oxidized LDL particles via upregulation of CD36.