Table 1.

Clinical conditions associated with disseminated intravascular coagulation.

Condition	Causes
Sepsis/severe infections	Gram-positive bacteria, Gram-negative bacteria, spirochetes, rickettsiae, protozoa, fungi, viruses
Trauma	Polytrauma, neurotrauma, fat embolism, burns
Malignancy	Solid tumors, myeloproliferative/lymphoproliferative malignancies
Obstetric complications	Amniotic fluid embolism, abruptio placentae, placenta previa, retained dead fetus syndrome
Vascular disorders	Large vascular aneurysms, Kasabach-Merritt syndrome
Organ destruction	Severe pancreatitis, severe hepatic failure
Toxic reactions	Snake bites, recreational drugs
Immunologic reactions	Hemolytic transfusion reaction, transplant rejection