LRS for regressed cortical and noncortical volume. The criteria LRS values for regressed cortical volume are 21.18 (highly significant at the genome-wide 0.001 level), 17.37 (significant at the genome-wide 0.05 level) and 9.91 (suggestive), following the conventions of Lander and Kruglyak [33]. The corresponding values for regressed noncortical brain volume are 20.90 (highly significant), 17.00 (significant) and 9.89 (suggestive). Genome-wide highly significant findings are marked by double asterisks, significant findings by a single asterisk. Chromosomal position is given in megabases.