Table 1.
Fold changes in selected genes treated with SB715992 tested by microarray analysis.
| Fold Change | |||||
| Accession Number | Gene Symbol | Description | 6 h | 24 h | 48 h |
| R64130 | PPBP | pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) | 1.07 | 1.74 | 6.50 |
| AI050866 | NODAL | nodal homolog (mouse) | 1.41 | 5.28 | 9.19 |
| NM_001106 | ACVR2B | activin A receptor, type IIB | 5.66 | 6.50 | 11.31 |
| NM_005118 | TNFSF15 | tumor necrosis factor (ligand) superfamily, member 15 | 1.23 | 4.92 | 11.31 |
| NM_005228 | EGFR | epidermal growth factor receptor | -1.52 | -1.15 | -2.00 |
| BC001971 | CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | 1.32 | 1.23 | 3.03 |
| BC000125 | TGFB1 | transforming growth factor, beta 1 (Camurati-Engelmann disease) | -1.41 | -1.23 | -2.00 |
| AA994334 | BCL10 | B-cell CLL/lymphoma 10 | 1.74 | 2.46 | 12.13 |
| AV654063 | KRAS2 | v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog | 18.38 | 13.00 | 19.70 |
| NM_004464 | FGF5 | fibroblast growth factor 5 | -1.32 | -7.46 | -6.06 |
| AK027071 | TSC22 | transforming growth factor beta 1 induced transcript 4 | NC | 2.83 | 5.28 |
| BG326045 | BHLHB2 | basic helix-loop-helix domain containing, class B, 2 | -1.15 | 2.64 | 9.19 |
| U73844 | ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific) | -1.07 | 2.64 | 6.96 |
| S75264 | WT1 | Wilms tumor 1 | -1.15 | -1.41 | -4.59 |
| AW514564 | CHD2 | chromodomain helicase DNA binding protein 2 | -1.07 | 3.48 | 14.93 |
| AF180474 | CNOT3 | CCR4-NOT transcription complex, subunit 3 | -1.52 | -2.14 | -4.29 |
| N95363 | CDKN1C | cyclin-dependent kinase inhibitor 1C (p57, Kip2) | -2.00 | 1.23 | 6.06 |
| AL039795 | TARDBP | TAR DNA binding protein | 1.52 | 4.29 | 10.56 |
| AK022513 | DUSP10 | dual specificity phosphatase 10 | -1.32 | 3.73 | 8.57 |
| AA994004 | CDK11 | cyclin-dependent kinase (CDC2-like) 11 | 8.57 | 8.00 | 128.00 |
| L78790 | ITGB2 | integrin, beta 2 (antigen CD18 (p95) | -1.23 | -1.32 | -10.56 |
| NM_003954 | MAP3K14 | mitogen-activated protein kinase kinase kinase 14 | -1.15 | -1.41 | -2.64 |
| NM_030662 | MAP2K2 | mitogen-activated protein kinase kinase 2 | -1.32 | -1.32 | -2.00 |
| AW025150 | MAP3K12 | mitogen-activated protein kinase kinase kinase 12 | 1.32 | -1.15 | -2.00 |
| AW450910 | SYK | spleen tyrosine kinase | -1.52 | -1.52 | -14.93 |
| M57765 | IL11 | interleukin 11 | 1.07 | -2.00 | -4.59 |
| AW444761 | CDKN2B | cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) | 1.07 | 6.06 | 9.19 |
| NM_002031 | FRK | fyn-related kinase | 4.29 | 6.96 | 25.99 |