Table 1.
Expression of cytokines in lung tissue from BALBcJ mice exposed to SRM1650
| Dose | Air | 20 mg/m3 DEP | 80 mg/m3 DEP | |||||
| Time | 1 h | 3 h | 1 day | 1 h | 3 h | 1 day | 1 h | 1 day |
| Tnf | 64 ± 23 | 41 ± 7.5 | 57 ± 43 | 49 ± 23 | 57 ± 7.7 | 100 ± 39 | 119 ± 70 | 178 ± 66** |
| Il-6 | 0.4 ± 0.3 | 0.2 ± 0.1 | 0.2 ± 0.1 | 1.0 ± 0.6** | 0.2 ± 0.2 | 0.2 ± 0.01 | 3.5 ± 1.5** | 0.9 ± 0.2** |
| Mcp-1 | 7.5 ± 4.7 | 21 ± 21 | 14 ± 20 | 8.5 ± 4.8 | 12.1 ± 3.4 | 11.6 ± 2.0 | 53.0 ± 57* | 129 ± 86** |
| Mip-2 | 20 ± 10 | 12 ± 5.7 | 22 ± 17 | 27.5 ± 18 | 12.6 ± 1.2 | 32.2 ± 10.1 | 63.4 ± 17.4* | 170 ± 66** |
| Kc | 4.0 ± 1.5 | 3.6 ± 1.5 | 2.7 ± 1.4 | 16.0 ± 4.8** | 4.5 ± 1.8 | 12.8 ± 6.5** | 17.8 ± 2.1** | 23.2 ± 11.5** |
Expression of mRNA is normalized to 18S rRNA and is multiplied by 107. Mean ± S.D. is shown (n = 3–7). IL-6 data has been published previously [8].
*P < 0.05 versus air-exposed mice.
**P < 0.01 versus air-exposed mice.