Table 3.
Inflammatory response in Tnf+/+ and Tnf-/- mice exposed to a single dose of 20 mg/m3 SRM2975
| Marker | Exposure | Air | DEP | ||
| Mice | 1 h | 1 day | 2 days | ||
| Tnf | Tnf +/+ | 47 ± 15 | 40 ± 9.3 | 89 ± 36 | 74 ± 34 |
| Il-6 | Tnf +/+ | 1.1 ± 0.8 | 3.0 ± 1.9 | 1.3 ± 0.8 | 1.7 ± 0.7 |
| Tnf -/- | 2.5 ± 1.6 | 4.8 ± 2.8 | 1.0 ± 0.4 | 2.6 ± 2.6 | |
| Mcp-1 | Tnf +/+ | 9.4 ± 2.6 | 21.9 ± 9.2 | 9.2 ± 3.9 | 15.4 ± 3.9 |
| Tnf -/- | 14.2 ± 9.1 | 39.5 ± 29.4 | 11.4 ± 4.4 | 33.5 ± 25 | |
| Mip-2 | Tnf +/+ | 8.1 ± 0.8 | 11.9 ± 1.2 | 19.5 ± 8.2* | 12.5 ± 2.6 |
| Tnf -/- | 6.6 ± 2.5 | 10.0 ± 6.8 | 8.6 ± 2.2 | 10.4 ± 5.2 | |
| Kc | Tnf +/+ | 1.5 ± 0.5 | 1.9 ± 0.6 | 2.8 ± 0.8 | 2.3 ± 1.3 |
| Tnf -/- | 1.3 ± 0.9 | 3.5 ± 2.2 | 1.5 ± 0.3 | 2.6 ± 0.7 | |
| Neutrophil (%) | Tnf +/+ | 0.2 ± 0.3 | 0.7 ± 0.3 | 3.8 ± 4.1** | 7.3 ± 5.8** |
| Tnf -/- | 0.4 ± 0.8 | 1.1 ± 1.3 | 0.9 ± 0.8 | 1.5 ± 1.0 | |
Tnf+/+ and Tnf-/- mice were exposed to a single dose of 20 mg/m3 SRM2975.
Expression of mRNA is normalized to 18S rRNA and is multiplied by 107. Mean ± S.D. is shown (n = 4–5).
*P < 0.05 versus air-exposed mice.
**P < 0.01 versus air-exposed mice.