Table 4.
Inflammatory response in Tnf+/+ and Tnf-/- mice exposed to multiple doses of 20 mg/m3 SRM2975
| Marker | Exposure | Air | DEP | ||
| Mice | Tnf+/+ | Tnf-/- | Tnf+/+ | Tnf-/- | |
| Tnf | 6.0 ± 4.4 | 13.8 ± 3.7* | |||
| Il-6 | 0.6 ± 0.4 | 1.2 ± 0.6 | 1.5 ± 0.4* | 4.2 ± 1.7** | |
| Mcp-1 | 11.0 ± 6.1 | 7.5 ± 3.8 | 17.9 ± 10.3 | 33.8 ± 16.6** | |
| Mip-2 | 6.5 ± 2.8 | 5.3 ± 2.5 | 22.9 ± 13.4** | 14.9 ± 7.0** | |
| Kc | 2.1 ± 1.0 | 1.2 ± 0.7 | 2.5 ± 0.8 | 4.7 ± 2.0** | |
| Neutrophil (%) | 3.4 ± 6.7 | 0.2 ± 0.3 | 12.3 ± 7.9** | 16.5 ± 10.1** | |
Expression of mRNA is normalized to 18S rRNA and is multiplied by 107. Mean ± S.D. is shown (n = 7–8). Neutrophil, TNF and IL6 data has been published previously [7].
*P < 0.05 versus air-exposed mice. **P < 0.01 versus air-exposed mice.