Table 3.
TLR ligand-induced cytokine/chemokine production in post-pubertal mice shows sexual dimorphism.
| TLR ligand | Cytokine/Chemokine | Male (pg/ml) | Female (pg/ml) |
| Media | IL-1α | 2.6 ± 0.5 | 3.8 ± 0.8 |
| IL-1β | 7.2 ± 2.3 | 6.5 ± 1.3 | |
| IL-6 | 39.7 ± 4.1 | 39.4 ± 10.2 | |
| IL-10 | 20.2 ± 3.5 | 27 ± 2.8 | |
| IL-12 | 4.1 ± 1.4 | 4.7 ± 1.1 | |
| IL-18 | 80.1 ± 17.2 | 46 ± 11.2 | |
| MCP-1 | 3.7 ± 0.4 | 17.3 ± 5.8* | |
| RANTES | 159.2 ± 56.5 | 171.4 ± 54.2 | |
| LPS | IL-1α | 24.5 ± 1.8 | 24.8 ± 5.2 |
| IL-1β | 29.1 ± 4.1 | 23.8 ± 3.6 | |
| IL-6 | 848.7 ± 154.4 | 1132.7 ± 323 | |
| IL-10 | 1484.5 ± 56.2 | 1960.5 ± 316.4 | |
| IL-12 | 12.7 ± 1.0 | 13.3 ± 1.1 | |
| IL-18 | 150.8 ± 10.8 | 151.8 ± 23.9 | |
| MCP-1 | 14.8 ± 2.7 | 21.2 ± 4.4 | |
| RANTES | 937.5 ± 369.8 | 1202.3 ± 567.4 | |
| LTA | IL-1α | 21.9 ± 0.9* | 14.6 ± 2.2 |
| IL-1β | 25.3 ± 4.3* | 11.9 ± 2.7 | |
| IL-6 | 214.2 ± 36.1 | 174.2 ± 48.3 | |
| IL-10 | 199.1 ± 21.3 | 210.7 ± 43.8 | |
| IL-12 | 9.5 ± 1.3 | 7.4 ± 0.5 | |
| IL-18 | 118.3 ± 6.0 | 94.1 ± 16.7 | |
| MCP-1 | 26.5 ± 3 | 32.2 ± 7.5 | |
| RANTES | 675.0 ± 228.5 | 772.4 ± 323.6 | |
| Poly I:C | IL-1α | 24.2 ± 1.9 | 20.0 ± 3.0 |
| IL-1β | 20.7 ± 2.1 | 13.8 ± 3.7 | |
| IL-6 | 201.4 ± 36.7 | 192.2 ± 45.59 | |
| IL-10 | 257.6 ± 17.8 | 298.1 ± 37.8 | |
| IL-12 | 6.7 ± 0.5 | 7.5 ± 0.5 | |
| IL-18 | 92.6 ± 12.2 | 105.8 ± 18.0 | |
| MCP-1 | 24.6 ± 2.3 | 31.3 ± 7.1 | |
| RANTES | 644.4 ± 236.3 | 980.7 ± 362.3 | |
| Imiquimod | IL-1α | 5.9 ± 0.8 | 7.3 ± 0.7 |
| IL-1β | 29.4 ± 7.2 | 28.2 ± 1.5 | |
| IL-6 | 4831.3 ± 1210.29 | 5256.1 ± 881.4 | |
| IL-10 | 1232.3 ± 272.3 | 1578.7 ± 145.9 | |
| IL-12 | 12.9 ± 1.7 | 14.5 ± 1.6 | |
| IL-18 | 137.1 ± 19.8 | 136.3 ± 15.0 | |
| MCP-1 | 28.6 ± 4.5 | 65.6 ± 13.9* | |
| RANTES | 632.1 ± 292.6 | 679.2 ± 273.1 | |
| Pam3CSK4 | IL-1α | 10.3 ± 6.9 | 3.2 ± 0.4 |
| IL-1β | 12.5 ± 3.5 | 6.5 ± 0.2 | |
| IL-6 | 272.9 ± 29.6 | 262.6 ± 59.4 | |
| IL-10 | 295.3 ± 30.6 | 351.8 ± 38.5 | |
| IL-12 | 5.4 ± 1.1 | 6.6 ± 1.2 | |
| IL-18 | 47.8 ± 17.0 | 80.9 ± 14.8 | |
| MCP-1 | 15.7 ± 1.4 | 40.2 ± 12.5 | |
| RANTES | 195.7 ± 68.3 | 279.2 ± 94.0 | |
| T1 CpG | IL-1α | 3.5 ± 1.0 | 3.5 ± 0.7 |
| IL-1β | 9.5 ± 2.2 | 7.7 ± 1.5 | |
| IL-6 | 169.5 ± 21 | 279.2 ± 44.7* | |
| IL-10 | 51.5 ± 9.8 | 80.6 ± 10.5* | |
| IL-12 | 6.0 ± 0.6 | 7.2 ± 1.2 | |
| IL-18 | 58.4 ± 7.1 | 96.5 ± 18.0 | |
| MCP-1 | 9.6 ± 3.1 | 43.5 ± 12.1* | |
| RANTES | 403.4 ± 158.7 | 619.3 ± 218.3 |
*Indicates statistical signifigance (p < 0.05)