Skip to main content
. Author manuscript; available in PMC: 2007 Apr 1.
Published in final edited form as: Am J Physiol Regul Integr Comp Physiol. 2005 Dec 1;290(4):R951–R962. doi: 10.1152/ajpregu.00734.2005

Figure 3.

Figure 3

PACAP27 (80 nM; A) and PACAP 38 (80 nM; B) increased detrusor smooth muscle tone whereas VIP only rarely resulted in changes in tone (D). These changes in detrusor tone were not blocked by tetrodotoxin (1 μM) suggesting a direct effect of PACAP on detrusor smooth muscle (D). PACAP27 or PACAP 38 (80 nM) potentiated the amplitude of nerve-evoked contractions at all frequencies tested (C) whereas no difference in electric field stimulation induced contraction amplitude was observed between time control and VIP-treated detrusor strips (C). *, p ≤ 0.001.