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The effect of OPN on the motility of WT (▪) and OPN−/− (□) osteoclasts. Motility of osteoclasts was assessed in vitro during both phagokinesis (A) and chemotaxis (B) assays. The treatments (OPN, 25 μg/ml; VN, 10 μg/ml; GRGDS, 50 μg/ml) are indicated at the bottom of the figures. Some cells were treated with an antibody to OPN, CD44, or integrin β3 (50 μg/ml) and OPN protein (25 μg/ml). The data are means ± SE (n = 3). ***p < 0.0001 vs. PBS; **p < 0.001 vs. OPN; *p < 0.01 vs. OPN.
