Table 1.

Quantitation of resorption pits generated in vitro by osteoclasts from WT and OPN−/− mice

	WT		OPN−/−
	PBS	OPN	PBS	OPN
Pit area (μm2)	875 ± 128	3782 ± 563a	228 ± 78	3228 ± 317b(a)
Pit depth (μm)	11.5 ± 2.1c	38.7 ± 3.6d	3.5 ± 0.35	3.97 ± 0.74

About 10–15 pits/slice and three slices from each experiment were quantitated. Data are means ± SE of three experiments. 

^a p < 0.001; OPN of WT and OPN−/− osteoclasts versus PBS of WT osteoclasts. 

^b p < 0.0001-OPN versus PBS of OPN−/− osteoclasts. 

^c p < 0.05; PBS of WT versus PBS and OPN of OPN−/− osteoclasts. 

^d p < 0.001; OPN versus PBS of WT osteoclasts.